Nonvenereal Syphilis (Endemic Syphilis)

Endemic syphilis (nonvenereal syphilis) is a treponemal endemic disease, not sexually transmitted. Spread by mucosal contact with contaminated utensils/cups/felt. Most common: secondary oral mucous patches. Untreated secondary endemic syphilis self-resolves in 6-9 months; tertiary causes gummatous skin/nasopharyngeal/bone ulcers. Single-dose benzathine penicillin treats patients and contacts.

Common Symptoms

Papule; condyloma

Causes and Pathogenesis

(1) Etiology: T. pallidum subsp. endemicum. (2) Pathogenesis: spread by mucosal contact with contaminated utensils/cups/felt; primary skin lesion is rare (likely oral/pharyngeal, unnoticed); most common is secondary oral mucous patches; untreated resolves in 6-9 months; tertiary gummas of skin/nasopharynx/bone.

Treatment

Drug therapy, supportive therapy

Preventive Measures

Mass treatment in endemic areas to eradicate reservoirs; improve public sanitation and socioeconomic conditions.

Department to Visit

It is recommended to visit the Infectious Diseases department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.