Progressive Supranuclear Palsy (PSP)

Progressive supranuclear palsy (PSP, Steele-Richardson-Olszewski syndrome) is an atypical parkinsonian neurodegenerative tauopathy. Clinical: early postural instability with falls, axial rigidity, supranuclear vertical gaze palsy, pseudobulbar signs, frontal cognitive decline, and personality change. It has poor response to levodopa. Treatment: supportive care, physical/occupational/speech therapy; levodopa trial usually limited; multidisciplinary.

Common Symptoms

Early falls; axial rigidity; supranuclear vertical gaze palsy; pseudobulbar signs; frontal cognitive decline; poor levodopa response

Causes and Pathogenesis

Tau-proteinopathy degenerates brainstem/basal-ganglia/frontal regions, producing axial parkinsonism + gaze palsy.

Treatment

Supportive; physical/occupational/speech therapy; levodopa trial (limited); multidisciplinary; manage falls

Preventive Measures

Fall prevention; multidisciplinary care; speech/swallow support.

Department to Visit

It is recommended to visit the Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.