Multiple System Atrophy (MSA)

Multiple system atrophy (MSA) is a progressive neurodegenerative alpha-synucleinopathy, with parkinsonism (MSA-P, striatonigral degeneration) or cerebellar ataxia (MSA-C, olivopontocerebellar atrophy), plus prominent autonomic failure (orthostatic hypotension, urinary incontinence/retention, erectile dysfunction). Onset in late adulthood; poor levodopa response. There is no disease-modifying therapy; treatment is supportive: manage orthostatic hypotension/urinary symptoms, rehab, and care as disease advances.

Common Symptoms

Parkinsonism/ataxia; orthostatic hypotension; urinary dysfunction; erectile dysfunction; poor levodopa response; late-adult onset

Causes and Pathogenesis

Alpha-synuclein glial cytoplasmic inclusions degenerate striatum/cerebellum/autonomic structures.

Treatment

Supportive; manage orthostatic hypotension/urinary; rehab; levodopa trial (poor response); care as advances

Preventive Measures

Supportive care; manage autonomic symptoms; fall prevention.

Department to Visit

It is recommended to visit the Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.