医
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面部皮肤皱纹增多、血尿、夜尿增多、食欲减退、胸闷、氮质血症、头晕、多尿、心悸
Analgesic nephropathy (AN) is chronic tubulointerstitial damage and/or renal papillary necrosis caused by long-term analgesic abuse when cumulative intake exceeds 1-2 kg, also called analgesic-induced chronic tubulointerstitial nephritis.
Increased facial wrinkles; hematuria; nocturia; anorexia; chest tightness; azotemia; dizziness; polyuria; palpitations
Long-term analgesic use for rheumatic fever, rheumatoid arthritis, migraine or dysmenorrhea leads to dependence; after years to decades with cumulative intake over 1-2 kg the disease develops, and over 6 kg damages the kidney in 50%-80%. Mechanism: components such as acetaminophen accumulate in the medulla and, via the cytochrome P-450 system, generate excess reactive oxygen species while inhibiting prostaglandin synthesis.
Stop analgesics, supportive treatment
Avoid long-term or excessive analgesic and NSAID use; monitor renal function.
It is recommended to visit the nephrology department; before the visit you may first book an appointment and connect with experts through this platform.
Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.
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