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Home > West Medicine > Internal Medicine > Hematology
C95.700x002

Congenital Leukemia (CL)

血液科

Common symptoms

疱疹、淋巴结肿大、出血倾向、颅内出血、食欲不振、黑便、呼吸急促、基因融合、流鼻血

The pathology of disease

Congenital leukemia (CL) is a rare type of leukemia diagnosed from birth to 8 weeks postnatally. Etiology/pathogenesis unclear; possibly genetic/constitutional/intrauterine factors. Often accompanied by congenital anomalies (trisomy 21, Turner syndrome, etc.).

Common Symptoms

Herpes; lymph-node enlargement; bleeding tendency; intracranial hemorrhage; anorexia; melena; tachypnea; gene fusion; epistaxis

Causes and Pathogenesis

(1) Etiology: unknown; neonatal constitution/genetics/intrauterine environment. Monozygotic twins: if one has leukemia <6y, co-twin risk 20% (usually within months). Dizygotic siblings 2-4x risk. Chromosomal abnormalities: trisomy 9/13, Turner, Down. May cause stillbirth (34-38w, hydrops fetalis); fetal/placental histology/IHC/electron microscopy may help. (2) Mechanism: unclear.

Treatment

Chemotherapy, surgery, supportive therapy

Preventive Measures

Exercise; optimism; emotional stability.

Department to Visit

It is recommended to visit the Hematology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.