Hereditary Spherocytosis

Hereditary spherocytosis is a hereditary hemolytic anemia with two inheritance patterns: autosomal dominant and autosomal recessive. Complications may include hemolytic crisis, cholelithiasis, gout, refractory ankle ulcers and lower-extremity erythematous ulcers.

Common Symptoms

Anemia; jaundice; splenomegaly

Causes and Pathogenesis

Hereditary spherocytosis is a congenital RBC-membrane defect causing spheroidal RBCs with increased osmotic fragility and splenic sequestration/destruction.

Treatment

Surgery, supportive therapy

Preventive Measures

Genetic counseling; splenectomy indicated for moderate/severe cases with folate supplementation.

Department to Visit

It is recommended to visit the Hematology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.