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寒战、无力、腹部不适、低分子蛋白尿、血红蛋白尿、恶心、腰背痛、蛋白尿
Paroxysmal cold hemoglobinuria (PCH) is a rare disease characterized by sudden hemoglobinuria after systemic or local cold exposure. Hemolysis is usually triggered by cold, but triggers may be subtle. Onset occurs minutes to hours later with brief chills and fever.
Dark urine after cold exposure; chills; fever; abdominal pain; anemia
Donath-Landsteiner antibody (IgG) binds RBCs at low temperature and fixes complement; on rewarming, complement-mediated intravascular hemolysis occurs. Often post-infectious (syphilis, viral) in children.
Avoid cold; supportive care; treat underlying infection
Avoid cold exposure; keep warm; treat associated infections/syphilis.
It is recommended to visit the Hematology department; an appointment can be booked on this platform before the visit.
Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.
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