Hemolytic Jaundice

Hemolytic jaundice is mainly due to intrinsic RBC defects or extrinsic injury causing massive RBC destruction and large hemoglobin release, raising plasma unconjugated (non-esterified) bilirubin; when this exceeds hepatocellular processing capacity, jaundice appears. Any disease causing hemolysis may produce hemolytic jaundice, including congenital hemolytic anemia and acquired hemolytic disorders.

Common Symptoms

Jaundice; anemia; splenomegaly; dark urine

Causes and Pathogenesis

Excess unconjugated bilirubin from hemolysis exceeds hepatic conjugation capacity; urine bilirubin is negative (unconjugated bilirubin not water-soluble), while urobilinogen increases.

Treatment

Treat underlying hemolytic disease; phototherapy in neonates; exchange transfusion if severe

Preventive Measures

Early detection and treatment of hemolytic disease.

Department to Visit

It is recommended to visit the Hematology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.