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Home > West Medicine > Internal Medicine > Hematology
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Disseminated Intravascular Coagulation

血液科

Common symptoms

昏迷、呼吸困难、咯血、腹痛、发绀、恶心、凝血因子功能的障碍、继发性纤溶功能增强、惊厥

The pathology of disease

Disseminated intravascular coagulation (DIC) is a syndrome of widespread intravascular clotting activation causing microthrombi in small vessels, consumption of platelets and coagulation factors, and secondary hyperfibrinolytic bleeding. Triggers: severe infection/sepsis, major trauma/burns, malignancy, obstetric complications (amniotic-fluid embolism, placental abruption), snake bite.

Common Symptoms

Widespread bleeding; petechiae/ecchymoses; hypotension; organ dysfunction; shock

Causes and Pathogenesis

Circulating procoagulants (tissue factor, bacterial endotoxin) activate global coagulation, forming microthrombi that consume platelets/factors; secondary fibrinolysis then causes bleeding.

Treatment

Treat underlying cause; supportive care; platelets/FFP/cryoprecipitate; heparin in selected cases

Preventive Measures

Early recognition and treatment of underlying trigger; close monitoring.

Department to Visit

It is recommended to visit the Emergency department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.