Lupus Erythematosus

Lupus erythematosus (cutaneous: DLE/sc/subacute/tumid/lupus profundus; systemic SLE) is autoimmune multisystem disease with photosensitive rash/joint pain/renal/hematologic/CNS involvement. Treatment: strict sun protection; topical/intralesional corticosteroids; topical calcineurin inhibitors; oral hydroxychloroquine; systemic corticosteroids for SLE; immunosuppressants (methotrexate/azathioprine/mycophenolate/cyclophosphamide); biologics (belimumab/rituximab); treat organ involvement (nephritis/neuropsychiatric/hematologic); monitor ANA/dsDNA/C3/C4/urinalysis/CBC; avoid smoking; pregnancy counseling; follow-up dermatology/rheumatology/nephrology.

Common Symptoms

Photosensitive rash (malar/disccoid/subacute); joint pain; renal/hematologic/CNS

Causes and Pathogenesis

Autoimmune B/T-cell dysregulation + UV + genetics causes multisystem inflammation.

Treatment

Sun protection; topical steroids; hydroxychloroquine; systemic immunosuppressants/biologics

Preventive Measures

Sun protection; avoid smoking; pregnancy counseling; monitor organs.

Department to Visit

It is recommended to visit the Dermatology/Rheumatology/Nephrology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.