Polymyositis

Polymyositis is idiopathic inflammatory myopathy with symmetric proximal muscle weakness, no rash. Clinical: proximal weakness (difficulty rising, climbing stairs), dysphagia, ILD. Diagnosis: muscle enzymes (CK, LDH, AST, ALT), EMG, MRI, muscle biopsy; myositis antibodies (anti-Jo-1, anti-SRP, anti-Mi-2). Treatment: glucocorticoids (oral prednisone/IV methylprednisolone); methotrexate/azathioprine/mycophenolate; IVIG; rituximab/cyclosporine for refractory; malignancy screening; physical/occupational therapy; monitor ILD (PFT/HRCT); follow-up rheumatology/neurology.

Common Symptoms

Proximal weakness; fatigue; dysphagia; no rash

Causes and Pathogenesis

Cell-mediated autoimmune myofiber inflammation.

Treatment

Glucocorticoids; methotrexate/azathioprine; IVIG; malignancy screen; PT

Preventive Measures

Malignancy screening; vaccination; bone protection.

Department to Visit

It is recommended to visit the Rheumatology/Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.