Necrotizing Vasculitis

Necrotizing vasculitis is characterized by fibrinoid necrosis of vessel walls with transmural inflammation, seen in PAN, ANCA-associated vasculitides. Clinical: systemic (fever, weight loss), skin (purpura/nodules/ulcers), mononeuritis multiplex, renal/pulmonary/GI/CNS ischemia. Diagnosis: biopsy, ANCA, ESR/CRP, imaging, angiography. Treatment: glucocorticoids (high-dose); cyclophosphamide or rituximab for induction; azathioprine/methotrexate maintenance; plasma exchange in selected (pulmonary hemorrhage/anti-GBM); treat triggers (infection/HBV/HCV); supportive; follow-up rheumatology/nephrology/neurology.

Common Symptoms

Fever; weight loss; purpura/nodules; mononeuritis multiplex; organ ischemia

Causes and Pathogenesis

Immune-mediated fibrinoid necrosis of vessel walls.

Treatment

Glucocorticoids; cyclophosphamide/rituximab; maintenance; PLEX if indicated

Preventive Measures

Early diagnosis; treat infection/HBV/HCV; organ monitoring.

Department to Visit

It is recommended to visit the Rheumatology/Nephrology/Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.