Iridocorneal Endothelial (ICE) Syndrome

Iridocorneal endothelial (ICE) syndrome is a unilateral disorder of young/middle-aged women with abnormal corneal endothelial cells proliferating across the angle, causing iris atrophy/holes, synechiae, and secondary (often difficult) glaucoma. Variants: progressive iris atrophy, Cogan-Reese, Chandler syndrome. Treatment: control secondary glaucoma (medications/tube shunt surgery); manage corneal edema (endothelial keratoplasty if needed); monitor long term.

Common Symptoms

Unilateral iris atrophy/holes; pigmented nodules; secondary glaucoma; corneal edema; young-mid women

Causes and Pathogenesis

Abnormal corneal endothelial membrane grows over angle, causing iris distortion, synechiae, and glaucoma.

Treatment

Control glaucoma (meds/tube shunt); endothelial keratoplasty for corneal edema; long-term follow-up

Preventive Measures

Glaucoma monitoring; manage corneal edema.

Department to Visit

It is recommended to visit the Ophthalmology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.