Chronic Progressive External Ophthalmoplegia (CPEO)

Chronic progressive external ophthalmoplegia (CPEO) is a mitochondrial myopathy causing gradual, painless ptosis and limitation of extraocular movements, often in young adults; may be part of Kearns-Sayre syndrome (with heart block/retinopathy). There is no curative therapy. Treatment: supportive; cardiac monitoring for heart block; ptosis/eye surgery cautiously; genetic/mitochondrial counseling.

Common Symptoms

Gradual painless ptosis; limited eye movements; young adult; possible heart block/retinopathy (Kearns-Sayre)

Causes and Pathogenesis

Mitochondrial DNA deletion causes progressive extraocular-muscle weakness.

Treatment

Supportive; cardiac monitoring; cautious ptosis surgery; mitochondrial/genetic counseling

Preventive Measures

Cardiac monitoring; genetic counseling.

Department to Visit

It is recommended to visit the Neurology/Ophthalmology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.