Fixed Drug Eruption

Fixed drug eruption is recurrent, well-demarcated violaceous/brownish plaque (often on genitalia/face/extremities) that recurs at the same site upon re-exposure to culprit drug (tetracyclines/NSAIDs/acetaminophen/codeine/sulfonamides). Treatment: identify/stop culprit drug; topical corticosteroids; oral antihistamines for pruritus; systemic steroids for generalized/bullous lesions; local care for blisters; post-inflammatory hyperpigmentation/hypopigmentation may persist; document drug allergy; follow-up.

Common Symptoms

Violaceous well-demarcated plaque; recurs at same site; by drug

Causes and Pathogenesis

Effector-memory T cells at fixed site reactivate on drug re-exposure.

Treatment

Stop drug; topical steroids; antihistamines; care for blisters

Preventive Measures

Document drug allergy; avoid culprit/cross-reactive drugs.

Department to Visit

It is recommended to visit the Dermatology/Allergy department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.