Psoriasis

Psoriasis is chronic immune-mediated inflammatory hyperproliferative dermatosis (plaque/guttate/pustular/inverse/erythrodermic), presenting with well-demarcated erythematous scaly plaques on extensor surfaces/scalp/lumbosacral, with nail pitting and pruritus. Treatment: topical corticosteroids + vitamin-D analogs (calcipotriol); coal tar; topical calcineurin inhibitors (for inverse/facial); phototherapy (NB-UVB/PUVA); systemic methotrexate/cyclosporine/acitretic acid; biologics: TNF inhibitors (etanercept/adalimumab/infliximab), IL-17 inhibitors (secukinumab/ixekizumab/brodalumab), IL-23 inhibitors (guselkumab/risankizumab/tildrakizumab); apremilast; JAK inhibitors upadacitinib; avoid triggers (stress/ infection/drugs: beta-blockers/Lithium/antimalarials); treat comorbidities (psoriatic arthritis/metabolic syndrome/CVD/IBD/depression); follow-up dermatology/rheumatology.

Common Symptoms

Well-demarcated erythematous scaly plaques; extensor/scalp/lumbosacral; nail pitting

Causes and Pathogenesis

IL-23/Th17 immune dysregulation causes keratinocyte hyperproliferation.

Treatment

Topical steroids/vitamin-D; phototherapy; methotrexate/cyclosporine; biologics

Preventive Measures

Avoid triggers; manage stress; treat comorbidities; cardiovascular risk control.

Department to Visit

It is recommended to visit the Dermatology/Rheumatology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.