Cholinergic Urticaria

Cholinergic urticaria is small pruritic punctate wheals on heat/exercise/emotional stress, in young adults, from cholinergic mast-cell activation. Treatment: H1 antihistamines (cetirizine/fexofenadine/hydroxyzine); avoid overheating/hot showers/spicy food; gradual exercise desensitization; cool clothing/environment; anticholinergics (disopyramide) for severe; omalizumab for refractory; monitor for anaphylaxis; follow-up allergy/dermatology.

Common Symptoms

Small punctate wheals; trunk/neck; after heat/exercise/emotion

Causes and Pathogenesis

Cholinergic sympathetic activation causes mast-cell degranulation.

Treatment

Antihistamines; avoid triggers; desensitization; omalizumab

Preventive Measures

Gradual exercise; cool environment; antihistamines.

Department to Visit

It is recommended to visit the Allergy/Dermatology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.