Lethal Midline Granuloma

Lethal midline granuloma is now recognized as extranodal NK/T-cell lymphoma, nasal type, causing progressive midline facial destruction (nose/palate/orbit). Clinical: nasal obstruction, crusting, ulceration, facial swelling, fever, weight loss. Diagnosis: biopsy (NK/T-cell phenotype, EBER+), imaging (CT/MRI/PET). Treatment: radiotherapy (localized) + chemotherapy (CHOP/EMOPDGE-L); L-asparaginase-based regimens; stem cell transplant in selected; supportive care; follow-up oncology/ENT.

Common Symptoms

Nasal obstruction; crusting; midline facial ulceration; fever; weight loss

Causes and Pathogenesis

EBV-positive NK/T-cell lymphoma causes midline destructive lesions.

Treatment

Radiotherapy; CHOP/EMOPDGE-L; L-asparaginase; transplant in selected

Preventive Measures

Early biopsy of midline lesions; prompt treatment.

Department to Visit

It is recommended to visit the Oncology/ENT/Hematology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.