Nonossifying fibroma

Non-ossifying fibroma (NOF) is a rare fibrous tissue tumor. It was once considered a tumor-like lesion, i.e. metaphyseal fibrous cortical defect; in 1942 Jaffe and Lichtenstein regarded it as a true tumor, and three years later Hatcher considered it a metaphyseal fibrous defect and tumor-like lesion; in 1958 Jaffe formally named it nonossifying fibroma. It is now mostly considered a benign fibrohistiocytic tumor.

Common Symptoms

Thinned cortex; bone pain; sclerosis

Causes

The cause is unknown. Grossly the tumor is well-demarcated, eccentric, firm or rubbery, cut surface yellow or dark brown, composed of lipid-containing yellow and tan fibrous connective tissue with brownish-yellow areas; local cortex is thinned and swollen with clear borders, surrounded by sclerotic or fibrous bone; adjacent cortex is intact unless pathologic fracture occurs; multiple foci may be lobulated, usually without periosteal reaction. Microscopically, spindle fibroblast proliferation in a storiform or whorled pattern with few collagen fibers; reticulin is usually abundant; hemorrhage and hemosiderin deposition may occur in the stroma, within spindle cells and multinucleated giant cells; focal clusters of foam cells are prominent; lipid- and hemosiderin-laden histiocytes are foam cells derived from fibroblasts; foam cells appear in 1/3 of cases, while some cases have much fibrous tissue and few foam cells; degenerating NOF has thickened collagen bundles resembling fibroma.

Treatment

Supportive treatment, rehabilitation therapy

Prevention

No specific effective prevention; adjust diet: 1. Maintain ideal weight. 2. Eat varied foods. 3. Include varied vegetables and fruit daily. 4. Eat more high-fiber foods such as whole grains, beans, vegetables and fruit. 5. Reduce total fat intake. 6. Limit alcohol. 7. Limit pickled, smoked and nitrite-containing foods.

Recommended Department

It is recommended to visit the oncologic surgery department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.