Merkel cell carcinoma

Merkel cell carcinoma, also called cutaneous trabecular carcinoma, primary cutaneous neuroendocrine carcinoma, primary small cell carcinoma of skin, or cutaneous APUDoma, was first reported by Toker in 1972. About 80% are associated with Merkel cell polyomavirus; the other 20% suggest other factors.

Common Symptoms

Nodule

Causes

Etiology unknown; possibly related to environment, genetics, diet, pregnancy emotion/nutrition. Pathologically: uniform round/oval cells in sheets, in dermis, often infiltrating subcutis/muscle; cells 2-3x mature lymphocytes, oval nuclei, fine dispersed chromatin, prominent nuclear membrane.

Treatment

Surgery; drug therapy; supportive care

Prevention

Keep the area clean; wash vulva daily; change underwear; avoid chronic discharge irritation. Nodules/ulcers/papillary masses or white lesions on vulva should be checked. Middle-aged/elderly women should have regular gynecologic screening; treat vulvar leukoplakia/papilloma early.

Recommended Department

It is recommended to visit the oncological surgery department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.