Sebaceous adenoma

Sebaceous adenoma is a benign tumor of nests of sebaceous cells, mostly forming small cystic spaces; stroma is fibrous connective tissue. Some show histiocytes/foreign-body giant cells without cholesterol crystals. Ductal dilatation or eosinophilic metaplasia may be present. Mucicarmine stains focal positive in ductal epithelium/luminal content; sebaceous cells negative.

Common Symptoms

Papule; nodule; fatigue

Causes

Benign tumor from incompletely differentiated sebaceous glands. Well-circumscribed, multilobulated, pseudocapsule, mid-lower dermis. Lobules contain two cell types: undifferentiated germinative cells (basal cells) at periphery, and mature sebaceous cells centrally, with transitional forms. Some lobules are mostly basaloid, others mostly mature sebaceous; most are roughly equal with germinative cells surrounding sebaceous nests. Fat stain shows lipid in sebaceous/transitional cells. Larger central cysts form from disintegrated sebaceous cells; squamous keratinizing foci represent ductal differentiation.

Treatment

Surgery; drug therapy; supportive care

Prevention

Etiology unclear; know risk factors; quit smoking, balanced diet, regular exercise, weight control reduce cancer risk.

Recommended Department

It is recommended to visit the oncological surgery department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.