Malignant fibrous histiocytoma

Malignant fibrous histiocytoma (MFH), also called malignant histiocytoma, is the most common soft tissue tumor of late adults. Pleomorphic highly cellular; lipid-laden vacuolated cells; mitoses frequent/atypical; vimentin positive. Post-op recurrence 25%, metastasis 35%, survival 50%. Variants: pleomorphic-storiform, myxoid, giant cell, inflammatory, angiomatoid.

Common Symptoms

Soft tissue swelling; anorexia

Causes

Arises from undifferentiated mesenchymal cells differentiating into fibroblasts/histiocytes. May be post-radiation (breast cancer, lymphoma, plasmacytoma, Hodgkin's). Gross: multilobulated gray-white, sometimes yellow/tan (lipid/hemosiderin); gelatinous in myxoid; blood-filled cysts in angiomatoid; yellow in inflammatory; may look cystic hematoma. Histology: storiform pattern (pinwheel), pleomorphic spindle/giant cells, foam cells, inflammation. Variants: (1) pleomorphic-storiform; (2) myxoid (>50% myxoid); (3) giant cell; (4) inflammatory (xanthogranuloma); (5) angiomatoid (children/young adults); (6) histiocytic. Differential: rhabdomyosarcoma, liposarcoma, dermatofibrosarcoma protuberans, nodular fasciitis, myxoma, epithelioid sarcoma, undifferentiated carcinoma, lymphoma.

Treatment

Supportive care; rehabilitation

Prevention

Ideal weight; varied diet; vegetables/fruits; high fiber; low fat; limit alcohol; limit pickled/smoked/nitrite foods.

Recommended Department

It is recommended to visit the oncological surgery department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.