Osteosarcoma

Osteosarcoma (osteogenic sarcoma) is a malignant connective tissue tumor where tumor cells directly produce osteoid/bone. Most common primary malignant bone tumor. Highly malignant, poor prognosis, lung metastasis within months; post-amputation 3-5y survival 5-20%. Metaphyses most common; 3/4 around distal femur/proximal tibia; also humerus/proximal femur/fibula/spine/ilium. Mostly osteolytic, some osteoblastic. Age 10-25, male > female. Types: telangiectatic, high-grade intracortical, high-grade intramedullary, round cell, parosteal, dedifferentiated parosteal.

Common Symptoms

Periosteal reaction; lung metastasis; recurrent childhood fractures; bone cyst; dyspnea; facial deformity; hemoptysis; knee pain; severe pain

Causes

Unknown. Internal: constitutional/genetic/endocrine; external: chemical/radiation/chronic inflammation/virus. Secondary to Paget disease, giant cell tumor, fibrous dysplasia (older patients). TCM: meridian blockage, qi/blood stasis.

Treatment

Surgery; supportive care; drug therapy

Prevention

Public education; avoid radiation; monitor benign lesions (osteochondroma, GCT, fibrous dysplasia). Unexplained periarticular pain in adolescents should be evaluated.

Recommended Department

It is recommended to visit the oncological surgery department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.