Chondrosarcoma

Chondrosarcoma is a malignancy of cartilage, mostly secondary to benign chondroid tumors (enchondroma, osteochondroma). Primary (young, high-grade, fast, poor) vs secondary (malignant change of benign tumor, late, slow, better, 4% of cases).

Common Symptoms

Fibrous dysplasia; bone cyst; bone pain; radiating pain

Causes

Arises from chondrocytes/mesenchyme in any endochondral bone. Extra chromosome 7; 17p1 abnormalities; CerbB-2 expression. Gross: >4 cm (50% >10 cm); central type destroys cortex/soft tissue; peripheral type is a large exophytic nodule. Cartilage cap >1 cm suspicious, >2 cm malignant (adults); children up to 2.5-3 cm. Micro: 4 grades (I-IV); grade I-II most common. Bizarre nuclei, binucleation, giant cells, mitoses in high-grade.

Treatment

Supportive care; rehabilitation; surgery

Prevention

Chromosomal hereditary disease; no effective prevention.

Recommended Department

It is recommended to visit the oncological surgery department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.