Giant cell tumor of bone

Giant cell tumor of bone (GCTB, osteoclastoma) is a common primary bone neoplasm; benign but locally aggressive; some consider it borderline malignant. Between benign and malignant; 1980 Musculoskeletal Tumor Society classified it as low-grade malignancy.

Common Symptoms

Limited shoulder motion; tibial pain; patellar pain

Causes

Unknown. Soft friable vascular granulation-like tissue with fibrous organization/hemorrhage. Three grades: I (benign, many giant cells, few mitoses), II (borderline, more stromal cells), III (malignant, sarcomatous stroma, few giant cells). Histology: multinucleated giant cells uniformly distributed among round/oval/spindle mononuclear stromal cells; nuclei similar; rich vascularity; hemorrhage/hemosiderin; only mononuclear stromal cells divide.

Treatment

Surgery; drug therapy; supportive care; rehabilitation

Prevention

Optimism; hygiene; exercise; diet (carotene/vitamin A, garlic/mushroom/kelp/tomato/spinach/cucumber/eggplant/dairy/soy/tea/royal jelly); quit smoking/limit alcohol.

Recommended Department

It is recommended to visit the oncological surgery department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.