Plasmacytoma

Plasmacytoma is a primary systemic malignant marrow tumor from B-lymphocytes differentiating to plasma cells. Solitary osseous plasmacytoma rare, curable. Multiple myeloma most common; osteolytic lesions and plasma cell marrow infiltration; anemia/hypergammaglobulinemia/hypercalcemia/renal impairment/infection.

Common Symptoms

Marrow plasmacytosis; radiating pain; amyloidosis; diffuse low back pain; fatigue; proteinuria; cord compression

Causes

Risk factors: high-dose ionizing radiation, chronic antigen stimulation, viral infection, chronic infection (osteomyelitis/pyelonephritis/TB). Age-related immune senescence; multi-step oncogenesis: thymic involution → polyclonal proliferation → random mutation. Familial. Gross: gray/red soft medullary, nodular, hemorrhagic/cystic/necrotic. Micro: dense plasma cell clusters; eccentric nuclei, clock-face chromatin, perinuclear hof.

Treatment

Drug therapy; supportive care

Prevention

Quit smoking; balanced diet; avoid spicy/overheated/cold/spoiled foods.

Recommended Department

It is recommended to visit the oncology department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.