Pulmonary Mucormycosis

Pulmonary mucormycosis is lung infection by Mucorales; underlying diabetes; high mortality. Amphotericin B + surgical debridement + treat comorbidities/electrolytes/acidosis improves mortality.

Common Symptoms

Coma; Zhan Siqiao; chest pain; somnolence; dyspnea; ptosis; abdominal pain; black palatal eschar

Causes and Pathogenesis

Zygomycotina/Mucorales/Mucoraceae: Rhizopus/Mucor/Absidia most common; R. arrhizus/orizae most common. Normal plasma inhibits Rhizopus; PMNs kill hyphae. Respiratory route; diabetes acidosis/hematologic malignancy/lymphoma/hypoplasia/steroids/chemo/radiation predispose. Nasal/submucosal growth → sinusitis/orbital cellulitis; direct brain/meningeal/lung invasion; spores cross bronchial walls → arterial thrombosis/acute purulent pneumonia/neutrophilic infiltrate/necrosis; angioinvasion accelerates spread and infarction. Pathology: vascular thrombosis + tissue necrosis.

Treatment

Drug therapy, supportive therapy

Preventive Measures

Treat underlying disease; avoid cross-infection; judicious immunosuppressants.

Department to Visit

It is recommended to visit the Respiratory department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.