Gilbert Syndrome

Gilbert syndrome is a common, benign inherited unconjugated hyperbilirubinemia due to reduced UDP-glucuronosyltransferase (UGT1A1) activity. It causes mild, fluctuating jaundice (especially with fasting, stress, illness) but no liver damage. It is benign and requires no treatment; reassure patient; distinguish from hemolysis/hepatitis.

Common Symptoms

Mild fluctuating jaundice; scleral icterus; triggered by fasting/stress/illness; otherwise asymptomatic

Causes and Pathogenesis

UGT1A1 promoter polymorphism reduces bilirubin conjugation, causing unconjugated hyperbilirubinemia without hemolysis or liver disease.

Treatment

Reassurance; no treatment needed; avoid prolonged fasting; recognize drug-therapy implications (irinotecan)

Preventive Measures

Reassurance; distinguish from hemolysis/hepatitis; note drug dosing implications.

Department to Visit

It is recommended to visit the Gastroenterology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.