Huntington Disease Dementia

Huntington disease dementia is the progressive subcortical cognitive decline that occurs in Huntington disease, accompanied by chorea and psychiatric symptoms (depression, apathy, irritability). Cognitive features: executive dysfunction, slowed processing, and memory impairment, eventually dementia. It is autosomal dominant (HTT CAG expansion). There is no disease-modifying therapy; treatment is supportive and symptomatic, with care as the disease advances.

Common Symptoms

Executive dysfunction; slowed processing; memory decline; chorea; depression/apathy; family history

Causes and Pathogenesis

HTT CAG-expansion mutation causes cortical/striatal neurodegeneration, producing subcortical dementia plus chorea.

Treatment

Supportive/symptomatic; treat chorea/psychiatric symptoms; caregiver support; genetic counseling

Preventive Measures

Genetic counseling; predictive testing with counseling; early supportive care.

Department to Visit

It is recommended to visit the Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.