Hereditary Spastic Paraplegia

Hereditary spastic paraplegia (familial spastic paraparesis) is a group of inherited neurodegenerative disorders characterized by progressive spastic weakness and gait disturbance of the legs, due to degeneration of the corticospinal tracts. It may be pure (leg spasticity alone) or complicated (with ataxia, neuropathy, cognitive impairment). Most are autosomal dominant. Onset varies. There is no cure; treatment is supportive with physical therapy, antispasticity agents (baclofen), and walking aids.

Common Symptoms

Progressive spastic leg weakness; stiff gait; urinary urgency; autosomal-dominant family history; variable age onset

Causes and Pathogenesis

Inherited mutations cause length-dependent corticospinal-tract axonal degeneration, producing progressive spastic paraparesis.

Treatment

Supportive; physical therapy; antispasticity agents (baclofen); walking aids; treat urinary symptoms

Preventive Measures

Genetic counseling; family screening; supportive rehab.

Department to Visit

It is recommended to visit the Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.