Central Pontine Myelinolysis (CPM)

Central pontine myelinolysis (osmotic demyelination syndrome) is demyelination in the central pons classically caused by overly rapid correction of chronic hyponatremia. Clinical: acute pseudobulbar palsy, flaccid then spastic quadriparesis, and altered consciousness ('locked-in' state in severe). MRI shows central pontine lesion. Prevention is key: correct hyponatremia slowly. Treatment: supportive care, slow sodium normalization, and rehab; recovery may be partial.

Common Symptoms

Pseudobulbar palsy; flaccid then spastic quadriparesis; altered consciousness; recent rapid sodium correction

Causes and Pathogenesis

Rapid correction of chronic hyponatremia causes osmotic demyelination of central pontine oligodendrocytes.

Treatment

Supportive; slow sodium correction; rehab; re-lowering sodium in selected cases

Preventive Measures

Correct hyponatremia slowly; monitor electrolytes.

Department to Visit

It is recommended to visit the Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.