Multifocal Motor Neuropathy

Multifocal motor neuropathy is an immune-mediated neuropathy characterized by progressive, asymmetric, distal limb weakness (especially hands), without sensory loss, due to multifocal motor-nerve conduction block, often with anti-GM1 antibodies. It can mimic motor-neuron disease. Diagnosis: electrophysiology showing conduction block, CSF (normal protein), anti-GM1. Treatment: IVIG is effective; immunosuppressants in selected cases; it does not respond well to steroids.

Common Symptoms

Progressive asymmetric distal weakness; hand weakness; no sensory loss; conduction block on EMG

Causes and Pathogenesis

Anti-GM1-mediated immune attack causes multifocal motor-nerve conduction block and weakness.

Treatment

IVIG; immunosuppressants in selected cases; avoid steroids (may worsen)

Preventive Measures

Early IVIG; PT; avoid steroids.

Department to Visit

It is recommended to visit the Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.