Nephrogenic diabetes insipidus

Nephrogenic diabetes insipidus is a disorder of tubular water reabsorption, presenting as polyuria, polydipsia and persistent hypotonic urine. Causes are hereditary or secondary; hereditary is an X-linked tubular disease, also called familial nephrogenic DI. Secondary forms occur in chronic kidney disease (obstructive nephropathy, interstitial nephritis, chronic pyelonephritis, hypercalcemia, potassium-wasting nephropathy, renal TB, medullary cystic disease), multiple myeloma, renal amyloidosis and drug damage (demeclocycline, methoxyflurane, vincristine).

Common Symptoms

Dehydration; polydipsia; postpartum frequency; convulsions; polyuria; dehydration; dilute urine

Causes

Either hereditary X-linked renal resistance to ADH, or acquired loss of the medullary hypertonic gradient from renal and extrarenal disease or drugs.

Treatment

Adequate water, thiazides, treat cause

Prevention

Ensure water intake, avoid precipitating drugs, and treat underlying disease.

Recommended Department

It is recommended to visit the nephrology department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.