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失眠、经常口渴、肾性尿崩、驻站医、肾上腺皮质激素不足、多饮、口渴、多尿、尿崩
Diabetes insipidus (DI) is passage of large volumes of dilute urine with thirst/polydipsia. Central (cranial) DI = ADH (vasopressin) deficiency from pituitary-hypothalamic disease (tumor, trauma, surgery, infiltrative); nephrogenic DI = renal collecting-duct resistance to ADH (hereditary V2 receptor/aquaporin-2 mutation, drugs such as lithium, hypercalcemia, hypokalemia). Water-deprivation test distinguishes; central DI responds to desmopressin.
Polyuria (3-20 L/day); polydipsia; dilute urine; nocturia; dehydration if thirst impaired; hypernatremia
Central: ADH deficiency causes impaired water reabsorption. Nephrogenic: renal collecting duct fails to respond to ADH, producing dilute urine regardless of ADH.
Central: desmopressin (DDAVP); nephrogenic: treat cause, thiazides, amiloride, low-solute diet; ensure free water access
Monitor urine output after pituitary surgery/trauma; avoid lithium where possible; ensure water access.
It is recommended to visit the Endocrinology department; an appointment can be booked on this platform before the visit.
Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.
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