医
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地图样骨缺损、骨骼肿块、心脏淤积淀粉样物质、骨质破坏、骨质疏松、骨痛、尿蛋白、弥漫性骨质疏松、穿凿样改变颅骨破坏
Multiple myeloma (MM, Kahler disease) is the most common plasma cell dyscrasia; monoclonal plasma cell proliferation secreting monoclonal immunoglobulin. Incidence 2-3/100,000; M:F = 1.6:1; >40 years; Black 2x White.
Map-like bone defect; bone mass; cardiac amyloid; bone destruction; osteoporosis; bone pain; proteinuria; diffuse osteoporosis; punched-out skull lesions
Radiation, chronic antigen stimulation, genetics, virus, gene mutations. Onset from earlier hematopoietic precursor; oncogenes; IL-6. Osteoclast-activating factors (IL-1, lymphotoxin, TNF, OAF); chromosome 6q deletion. Hyperviscosity, renal light-chain damage, amyloidosis (8-15%), immunosuppression.
Drug therapy; supportive care; radiotherapy
Avoid radiation/toxins; regular exercise; hygiene; treat chronic disease.
It is recommended to visit the hematology department; before the visit you may first book an appointment and connect with experts through this platform.
Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.
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