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Home > West Medicine > Internal Medicine > Hematology
百科

Prolymphocytic leukemia

血液科

Common symptoms

淋巴结肿大、出血倾向、体重减轻、胸腔积液、腹水、口腔溃疡、低热

The pathology of disease

Prolymphocytic leukemia (PLL) is a rare lymphocytic leukemia; middle-aged/elderly (>50); male predominance; peripheral B- or T-cell tumor.

Common Symptoms

Lymphadenopathy; bleeding tendency; weight loss; pleural effusion; ascites; oral ulcer; low fever

Causes

Sex predilection. Cytogenetics: 14q abnormality in 60%; 12 trisomy (less than CLL); 6q-; t(6;12); t(2;13). 80% B-PLL (monoclonal Ig rearrangement, surface IgM, CD5+ in half, SN8 differentiates); 20% T-PLL (CD2/CD4/CD8/CD7, alpha-naphthyl esterase positive).

Treatment

Drug therapy; supportive care

Prevention

Comprehensive care; bland diet; fresh vegetables/seafood.

Recommended Department

It is recommended to visit the hematology department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.