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淋巴结肿大、无力、肝脾肿大、肉芽肿、咯血、盗汗、免疫力降低、气急
Histoplasmosis capsulati is a worldwide granulomatous disease caused by Histoplasma capsulatum var. capsulatum.
Lymphadenopathy; weakness; hepatosplenomegaly; granuloma; hemoptysis; night sweats; reduced immunity; dyspnea
(1) Etiology: 3 varieties: capsulatum, duboisii, farciminosum; teleomorph Ajellomyces. Darling 1905 Panama Canal Zone; Dubois 1952 South Africa; Week 1985. Soil/airborne; infects horses/dogs/cats/rats. 22-29°C, 67-87% RH = tropical/subtropical/temperate; rare in Europe. (2) Pathogenesis: pulmonary histoplasmosis: inhaled dust → acute infection; 95% asymptomatic → calcification; skin test/culture positive; CXR: scattered infiltrates/hilar nodes/calcifications. Disseminated: benign (calcifications) or progressive/fulminant; progressive in adults (severe symptoms, hepatosplenomegaly); fulminant in infants (rapid death).
Drug therapy, supportive therapy
Laboratory precautions; new arrivals; bird/bat caves.
It is recommended to visit the Hematology department; an appointment can be booked on this platform before the visit.
Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.
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