医
China Med Service
Best doctors, yours
Breaking down language, channel and process barriers in cross-border care — making the best doctors your personal doctors.
300 Grade-A partner hospitals · 3,000+ leading experts · one-stop service across all specialties
淋巴结肿大、出血倾向、体重减轻、胸腔积液、腹水、口腔溃疡、低热
Prolymphocytic leukemia (PLL) is a rare special type of lymphocytic leukemia; middle-aged/elderly (>50y), male predominance; peripheral lymphoid tumor of B- or T-cell origin.
Lymph-node enlargement; bleeding tendency; weight loss; pleural effusion; ascites; oral ulcer; low fever
Etiology unknown; sex predisposition. Cytogenetics: ~60% have 14q abnormality; trisomy 12 less than CLL; 6q-; t(6;12)(q15;q14); t(2;13)(q35;q14) (rhabdomyosarcoma change, also in B-PLL). Immunogenetics: 80% B-PLL (monoclonal Ig rearrangement; B-surface antigens; high surface IgM +/- IgD; no mouse RBC rosette; 50% CD5+; SN8 distinguishes from CLL/HCL). 20% T-PLL (CD2+; sheep RBC rosette; 75% CD4+, 20% CD8+, 15% CD4+CD8+; CD7+, CD1/HLA-DR/TdT-; alpha-nonspecific esterase positive, large-granule type).
Drug, supportive therapy
No effective prevention; early diagnosis/treatment. Comprehensive treatment (physical/psychological/diet). Light diet; fresh vegetables/seafood.
It is recommended to visit the Hematology department; an appointment can be booked on this platform before the visit.
Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.
|
