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颈强直、颅内出血、三叉神经一二支...、面神经瘫痪、凝血障碍、血小板减少、抽搐、神志不清、颅内压增高、脊髓出血
CNS leukemia (CNS-L) refers to clinical signs/symptoms from extramedullary leukemic-cell infiltration of the leptomeninges or adjacent neural tissue; a common leukemia complication with major prognostic impact. Causes corresponding neurologic/psychiatric symptoms. Leukoencephalopathy can occur at any stage.
Neck stiffness; intracranial hemorrhage; trigeminal V1/V2; facial palsy; coagulopathy; thrombocytopenia; convulsions; altered consciousness; raised ICP; spinal-cord hemorrhage
Chemical leukemogens: benzene/nitrosamines/phenylbutazone/chloramphenicol; cytotoxic chemo (nitrogen mustard/cyclophosphamide/procarbazine/VP16/VM26). Ionizing radiation (dose-dependent; Co-60 exposure). RNA retroviruses (T-cell type). Chromosomal aberrations.
Drug, supportive therapy
(1) Patient education; bed rest; minimize visitors. (2) Clean disinfected ward; no smoking; light diet; regular bowel. (3) Monitor mental status/vitals/temperature/pulse/respiration/BP.
It is recommended to visit the Hematology department; an appointment can be booked on this platform before the visit.
Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.
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