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寒战、昏迷、休克、背痛、腹泻、头昏、免疫性溶血
Warm-antibody autoimmune hemolytic anemia: autoantibodies optimally react with RBCs at 35-40C (warm antibodies). They are divided into incomplete warm antibodies and warm autoimmune hemolysins. By chemical structure, warm antibodies are IgG, IgM or IgA; IgG warm antibodies are further divided into IgG1, IgG2, IgG3 and IgG4 subtypes.
Anemia; jaundice; splenomegaly; dark urine
IgG warm antibodies bind RBCs at body temperature; splenic macrophages phagocytose antibody-coated RBCs (extravascular hemolysis); complement activation may occur. Primary or secondary to CLL, lymphoma, SLE, drugs (alpha-methyldopa). Direct antiglobulin test (DAT/Coombs) positive.
Corticosteroids; IVIG; splenectomy; immunosuppressants; rituximab
Treat underlying disease; avoid offending drugs; monitor.
It is recommended to visit the Hematology department; an appointment can be booked on this platform before the visit.
Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.
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