Hereditary Protein-S Deficiency

Hereditary protein-S deficiency is an autosomal-dominant thrombophilia. Protein S serves as a cofactor for activated protein C in inactivating factors Va/VIIIa; deficiency increases venous-thrombosis risk (DVT, pulmonary embolism).

Common Symptoms

Deep-vein thrombosis; pulmonary embolism; recurrent thrombophlebitis

Causes and Pathogenesis

Mutations in the PROS1 gene reduce free protein-S levels, impairing APC-mediated anticoagulation and predisposing to venous thrombosis.

Treatment

Anticoagulation; prophylaxis during high-risk periods

Preventive Measures

Avoid prolonged immobilization; anticoagulant prophylaxis; genetic counseling.

Department to Visit

It is recommended to visit the Hematology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.