Rheumatic Fever

Rheumatic fever is a delayed autoimmune complication of group A streptococcal pharyngitis, occurring in children, presenting with Jones-criteria: migratory polyarthritis, carditis (pancarditis), Sydenham chorea, erythema marginatum, and subcutaneous nodules, plus evidence of preceding strep (elevated ASO). It causes chronic rheumatic valvular disease. Treatment: eradicate streptococcus (penicillin); anti-inflammatory (aspirin/steroids for carditis); long-term secondary penicillin prophylaxis to prevent recurrence and valvular damage.

Common Symptoms

Migratory polyarthritis; carditis; chorea; erythema marginatum; subcutaneous nodules; child after strep pharyngitis; elevated ASO

Causes and Pathogenesis

Antibodies to group A strep cross-react with cardiac/joint/brain tissue (molecular mimicry).

Treatment

Penicillin to eradicate strep; aspirin/steroids for inflammation; long-term secondary penicillin prophylaxis

Preventive Measures

Treat strep pharyngitis promptly; secondary prophylaxis after RF.

Department to Visit

It is recommended to visit the Pediatrics/Cardiology/Rheumatology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.