Microscopic Polyangiitis

Microscopic polyangiitis is an ANCA-associated necrotizing small-vessel vasculitis, predominantly affecting kidneys (pauci-immune crescentic glomerulonephritis) and lungs (pulmonary capillaritis/hemorrhage). Treatment: induction with high-dose glucocorticoids plus rituximab or cyclophosphamide; maintenance with azathioprine/rituximab; dialysis/respiratory support as needed; PCP prophylaxis; long-term monitoring of relapse and renal function.

Common Symptoms

Hematuria/renal failure; hemoptysis/pulmonary infiltrates; fever/weight loss; mononeuritis multiplex

Causes and Pathogenesis

MPO-ANCA causes necrotizing small-vessel vasculitis, affecting kidneys/lungs/skin/nerves.

Treatment

Glucocorticoids + rituximab/cyclophosphamide; maintenance; organ support; prophylaxis

Preventive Measures

Early diagnosis; monitor renal/pulmonary; vaccination; prophylaxis.

Department to Visit

It is recommended to visit the Rheumatology/Nephrology/Pulmonology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.