Felty Syndrome

Felty syndrome is complication of seropositive rheumatoid arthritis: chronic RA + neutropenia + splenomegaly, with increased infection risk, leg ulcers, thrombocytopenia. Treatment: optimize RA therapy (methotrexate/leflunomide; biologics: TNF inhibitors/rituximab); G-CSF (filgrastim) for severe neutropenia; splenectomy for refractory neutropenia/infection; treat infections promptly; antibiotics prophylaxis as needed; monitor CBC; follow-up rheumatology/hematology; screen for infection; distinguish from large granular lymphocytic leukemia.

Common Symptoms

Chronic RA; neutropenia; splenomegaly; recurrent infections; leg ulcers

Causes and Pathogenesis

Autoimmune neutrophil destruction + hypersplenism causes neutropenia in long-standing RA.

Treatment

Optimize RA (DMARDs/biologics); G-CSF; splenectomy; treat infections

Preventive Measures

Optimize RA control; monitor CBC; prompt infection care.

Department to Visit

It is recommended to visit the Rheumatology/Hematology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.