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Home > West Medicine > Internal Medicine > Rheumatology
M10.900x093

Tophus (Gouty Tophus)

风湿免疫科

Common symptoms

尿酸结晶、痛风结节

The pathology of disease

Tophus (gouty tophus) is deposition of monosodium urate crystals in soft tissue (ear helix/fingertips/olecranon/patellar bursa) or joints, in chronic gout. Treatment: urate-lowering therapy (allopurinol/febuxostat) to SUA <5 mg/dL; low-purine diet; avoid alcohol/fructose; hydration; treat CKD/comorbidities; surgical excision for large/deforming/ulcerated/infected tophi; wound care; follow-up rheumatology; monitor tophus resolution/renal stones.

Common Symptoms

Hard subcutaneous nodule; ear/fingertips/bursa; chronic gout; urate crystals

Causes and Pathogenesis

Chronic hyperuricemia causes MSU crystal deposition and foreign-body granuloma (tophus).

Treatment

ULT (allopurinol/febuxostat); low-purine diet; hydration; surgical excision if large

Preventive Measures

Aggressive urate lowering; diet; hydration; treat CKD.

Department to Visit

It is recommended to visit the Rheumatology/Surgery department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.

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