Systemic Lupus Erythematosus (SLE)

Systemic lupus erythematosus (SLE) is autoimmune multisystem disease with ANA/anti-dsDNA/anti-Smith. Clinical: malar rash, photosensitivity, oral ulcers, arthritis, serositis, renal/neuro/hematologic/cardiac/pulmonary involvement. Diagnosis: SLICC/ACR criteria. Treatment: hydroxychloroquine (all SLE, base therapy); glucocorticoids (topical/oral/IV pulses) by severity; immunosuppressants (mycophenolate, azathioprine, methotrexate, cyclophosphamide) for organ involvement; belimumab/rituximab in refractory; avoid UV/sun; manage fatigue, cardiovascular risk, bone protection, vaccination; monitor CBC, urinalysis, anti-dsDNA, complements, ESR/CRP, C3/C4, eGFR; follow-up rheumatology/nephrology/neurology/dermatology.

Common Symptoms

Malar rash; photosensitivity; arthritis; fatigue; fever; organ involvement

Causes and Pathogenesis

Autoimmune B/T-cell dysregulation with autoantibodies (ANA, anti-dsDNA) causes multisystem inflammation.

Treatment

Hydroxychloroquine; glucocorticoids; immunosuppressants; biologics; avoid UV

Preventive Measures

Avoid UV; treat infection; cardiovascular risk; bone protection; vaccination.

Department to Visit

It is recommended to visit the Rheumatology/Nephrology/Dermatology/Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.