Mixed Connective Tissue Disease (MCTD)

Mixed connective tissue disease (MCTD) is overlap syndrome with high-titer anti-U1-RNP, combining SLE, scleroderma, and polymyositis features. Clinical: Raynaud phenomenon, swollen hands/sclerodactyly, arthritis/myositis, esophageal dysmotility, interstitial lung disease (ILD), pulmonary hypertension, renal involvement. Diagnosis: ANA + anti-U1-RNP; clinical overlap. Treatment: hydroxychloroquine base; glucocorticoids by severity; immunosuppressants (methotrexate/azathioprine/mycophenolate/cyclophosphamide); ACEi for renal; pulmonary hypertension therapy (bosentan/sildenafil/epoprostenol); manage Raynaud (calcium-channel blockers, bosentan, iloprost); physical therapy; monitor CBC, urinalysis, PFT/HRCT, echocardiography; follow-up rheumatology/pulmonology/nephrology.

Common Symptoms

Raynaud; swollen hands; arthritis; myositis; ILD; pulmonary HTN

Causes and Pathogenesis

Autoimmune overlap with anti-U1-RNP antibodies.

Treatment

Hydroxychloroquine; glucocorticoids; immunosuppressants; pulmonary HTN therapy

Preventive Measures

Avoid cold/smoking; monitor organs; vaccination.

Department to Visit

It is recommended to visit the Rheumatology/Pulmonology/Nephrology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.