Inclusion-Body Myositis

Inclusion-body myositis is the most common acquired myopathy in older adults, characterized by slowly progressive, asymmetric weakness of distal fingers and quadriceps, with muscle biopsy showing rimmed vacuoles/inclusion bodies. It does not respond well to immunosuppression. Treatment: supportive care, physical/occupational therapy, and falls prevention; immunosuppression is generally ineffective; some trialing of IVIG.

Common Symptoms

Slowly progressive asymmetric weakness; finger flexors/quadriceps; older adults; falls; no good response to steroids

Causes and Pathogenesis

Debate: degenerative/autoimmune; rimmed-vacuole inclusion-body myofibers cause progressive weakness.

Treatment

Supportive; physical/occupational therapy; falls prevention; immunosuppression generally ineffective

Preventive Measures

Falls prevention; rehab; mobility aids.

Department to Visit

It is recommended to visit the Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.