Drug-induced Cirrhosis

Drug-induced cirrhosis is end-stage fibrotic nodular liver from chronic drug/herbal toxicity (methotrexate/isoniazid/ amiodarone/herbals), presenting with portal hypertension and synthetic dysfunction. Treatment: discontinue culprit drug; treat complications (varices/ascites/encephalopathy/SBP); screen for hepatocellular carcinoma; nutritional support; liver transplant evaluation; monitor for recovery vs progression; avoid hepatotoxins; follow-up.

Common Symptoms

Ascites; varices; encephalopathy; by chronic drug/herbal toxicity

Causes and Pathogenesis

Chronic drug toxicity causes fibrosis/nodular regeneration and portal hypertension.

Treatment

Stop culprit; treat complications; screen HCC; transplant eval

Preventive Measures

Monitor liver enzymes on hepatotoxic drugs; avoid unregulated herbals.

Department to Visit

It is recommended to visit the Gastroenterology/Hepatology/Transplant department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.