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卵巢萎缩、甲状腺功能低下、泌尿系感染、绝经期面红、盗汗、脱发、便秘、女性第二性征消失、抗卵巢抗体阳性、闭经
Premature ovarian failure (primary ovarian insufficiency, POI) is cessation of ovarian function before age 40, with amenorrhea, hypoestrogenism, and elevated FSH (menopausal range). Causes: autoimmune oophoritis, genetic (Turner syndrome, Fragile-X premutation), iatrogenic (chemotherapy/radiotherapy/surgery), idiopathic. Clinical: amenorrhea/oligomenorrhea, hot flushes, dyspareunia, infertility, low bone density. Treatment: hormone replacement until natural menopause age; fertility counseling/donor oocyte.
Amenorrhea/oligomenorrhea; hot flushes; night sweats; dyspareunia; infertility; low libido; low bone density
Depletion/destruction of ovarian follicles (autoimmune, genetic, iatrogenic) reduces estrogen and inhibin, with loss of negative feedback and elevated FSH.
Estrogen/progestin HRT until ~51; calcium/vitamin D/bone protection; fertility counseling; treat associated autoimmune disease
Fertility preservation before chemo/radiation; genetic counseling; bone-health monitoring.
It is recommended to visit the Endocrinology department; an appointment can be booked on this platform before the visit.
Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.
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